RNA polymerase I–Rrn3 complex at 4.8 Å resolution
نویسندگان
چکیده
Transcription of ribosomal DNA by RNA polymerase I (Pol I) requires the initiation factor Rrn3. Here we report the cryo-EM structure of the Pol I-Rrn3 complex at 4.8 Å resolution. The structure reveals how Rrn3 binding converts an inactive Pol I dimer into an initiation-competent monomeric complex and provides insights into the mechanisms of Pol I-specific initiation and regulation.
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Structure of the initiation-competent RNA polymerase I and its implication for transcription
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